2-Phenylthiophene → 2-(5-Bromo-2-methylbenzyl)-5-phenylthiophene

Reaction equation

[C:1]1([C:7]2[S:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:12][C:13]1[CH:14]=[CH:15][C:16]([CH3:22])=[C:17]([CH:21]=1)[C:18](O)=O>>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([CH3:22])=[C:17]([CH2:18][C:9]2[S:8][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:11][CH:10]=2)[CH:21]=1

Participants

Reactant 2

HCID 699992-Phenylthiophene

HCID 3460045-Bromo-2-methylbenzoic acid

Product 1

HCID 666083062-(5-Bromo-2-methylbenzyl)-5-phenylthiophene

Procedure

2-Phenylthiophene and 5-bromo-2-methylbenzoic acid obtained in Reference Example 4-(1) were treated in a manner similar to Reference Example 5 to give the target compound. APCI-Mass m/Z 343/345 (M+H).

Workup

addition4-(1) were treated in a manner similar to Reference Example 5
customto give the target compound

Sources & evidence

ORD record: ord-a0b4703a02474cab9a595999e67115eb
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08202984B2

Reaction notes

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