4-Chloro-2,2-dimethylbutanenitrile → HCID 19375650, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15](CCCCN)[CH2:14][CH2:13]2)[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1.Cl[CH2:24][CH2:25][C:26]([CH3:30])([CH3:29])[C:27]#[N:28]>>[Cl:1][C:2]1[CH:3]=[C:4]([N:12]2[CH2:17][CH2:16][N:15]([CH2:24][CH2:25][C:26]([CH3:30])([CH3:29])[CH2:27][NH2:28])[CH2:14][CH2:13]2)[C:5]2[O:10][CH2:9][CH2:8][O:7][C:6]=2[CH:11]=1Participants
3
Procedure
The intermediate 1-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-4-(4-amino-3,3-dimethylbutyl)piperazine was prepared analogous to the method described for 1-(7-chloro-2,3-dihydro-1,4-benzodioxin-5-yl)-4-(4-aminobutyl)piperazine (Intermediate 11b) using 4-chloro-2,2-dimethylbutyronitrile.
Sources & evidence
- ORD record
- ord-39825e3ba0cf42aea496895a9727a23b
- Source dataset
- uspto-grants-1995_10
- Patent number