(2E)-3-(4-((Methylsulfonyl)oxy)phenyl)-2-propenoic acid → (E)-3-(4-(trifluoromethylsulfonyloxy)phenyl)acrylic acid
Reaction equation
CS(O[C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)(=O)=O.CS(Cl)(=O)=O.[F:22][C:23]([F:36])([F:35])[S:24]([O:27]S(C(F)(F)F)(=O)=O)(=[O:26])=[O:25]>>[F:22][C:23]([F:36])([F:35])[S:24]([O:27][C:6]1[CH:11]=[CH:10][C:9](/[CH:12]=[CH:13]/[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1)(=[O:26])=[O:25]Participants
3
Procedure
13.4 g of (E)-3-(4-(trifluoromethylsulfonyloxy)phenyl)acrylic acid was synthesized as described for (E)-3-(4-(methanesulfonyloxy)phenyl)acrylic acid using trifluoromethansulfonic acid anhydride methanesulfonyl chloride.
Sources & evidence
- ORD record
- ord-d9d34d4d76dc4bf28262886936d523c5
- Source dataset
- uspto-grants-2006_09