HCID 21055320, compound → HCID 21055321, compound

Reaction equation

C[C@H](CSC1C=CC=CC=1OC)CO.[CH2:15]([C@H:17]([CH2:20][S:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])[CH2:18][OH:19])[CH3:16]>>[CH2:15]([C@H:17]([CH2:20][S:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[O:28][CH3:29])[CH:18]=[O:19])[CH3:16]

Participants

Reactant 2

HCID 21055320HCID 21055320, compound

HCID 21055336HCID 21055336, compound

Product 1

HCID 21055321HCID 21055321, compound

Procedure

The title compound (IId-1) is obtained by carrying out the preparation as in example 7 but by replacing, in stage 2, 2-(S)-methyl-3-(2-methoxyphenylthio)propan-1-ol (XXb-1) with 2-(S)-ethyl-3-(2-methoxy-phenylthio)propan-1-ol (XXd-1). This title compound, like the aldehyde (IIb-1), is not isolated but is used in situ in the following reductive amination reaction.

Workup

customthe preparation as in example 7

Sources & evidence

ORD record: ord-4d2a95291f04459285c1a35ac27b51f7
Source dataset: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07109234B2

Reaction notes

Loading…