HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzo(b)thiophene-2-carboxylic acid → N-[3-cyano-4-(4-methylpiperazin-1-yl)phenyl]benzo[b]thiophene-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzo(b)thiophene-2-carboxylic acid | HCID 95864 | — |
| Reactant | 5-Amino-2-(4-methylpiperazin-1-yl)benzonitrile | HCID 17609581 | — |
| Product | N-[3-cyano-4-(4-methylpiperazin-1-yl)phenyl]benzo[b]thiophene-2-carboxamide | HCID 21942320 | 36.4% |
Reaction Steps
By the reaction and treatment in the same manner as in Example 6 using benzo[b]thiophene-2-carboxylic acid (1.3 g) and 5-amino-2-(4-methylpiperazin-1-yl)benzonitrile (1.6 g), the title compound (1.0 g) was obtained. melting point: 263-264° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07112594B2 |
| Source dataset | uspto-grants-2006_09 |
| ORD ID | ord-bd29e0bf0edf4d8c8ad09f2b0e801b45 |
| Source note | uspto-grants-2006_09 |