5-Aminoquinoline → HCID 59768622, compound

HRID 2217812

Reaction equation

HRID 2217812 reaction equation
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:12][C:13]1([CH2:19][C:20](O)=[O:21])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH3:12][C:13]1([CH2:19][C:20]([NH:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][CH:2]=[N:1]3)=[O:21])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 119115-AminoquinolineHCID 136978852-(1-Methylcyclohexyl)acetic acid

Product 1

HCID 59768622HCID 59768622, compoundYield 17.8%

Procedure

Prepared according to the method of example 18, using 5-quinolinamine (230 mg) and 1-methyl-cyclohexaneacetic acid (250 mg). Purification (SiO2, methanol:dichloromethane 1:9 as eluant) followed by recrystallisation from methanol/ethyl acetate gave the title compound as a colourless solid (80 mg).

Workup

  1. customPrepared
  2. customPurification (SiO2, methanol:dichloromethane 1:9 as eluant)
  3. customfollowed by recrystallisation from methanol/ethyl acetate

Sources & evidence

ORD record
ord-7a1c2afd8ea74b80b3c13d9496684e3a
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Linked notes

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