3-(Hydroxymethyl)pyridazine → 5-Chloro-N-[5-methyl-3-(3-pyridazinylmethoxy)-2-pyrazinyl]-2-thiophenesulphonamide

HRID 2217980

Reaction equation

HRID 2217980 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][OH:8])[N:2]=1.[Cl:9][C:10]1[S:14][C:13]([S:15]([NH:18][C:19]2[C:24](Br)=[N:23][C:22]([CH3:26])=[CH:21][N:20]=2)(=[O:17])=[O:16])=[CH:12][CH:11]=1>>[Cl:9][C:10]1[S:14][C:13]([S:15]([NH:18][C:19]2[C:24]([O:8][CH2:7][C:3]3[N:2]=[N:1][CH:6]=[CH:5][CH:4]=3)=[N:23][C:22]([CH3:26])=[CH:21][N:20]=2)(=[O:16])=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 27945753-(Hydroxymethyl)pyridazineHCID 103092085-Chloro-N-(3-bromo-5-methyl-2-pyrazinyl)-2-thiophenesulphonamide

Product 1

HCID 103096575-Chloro-N-[5-methyl-3-(3-pyridazinylmethoxy)-2-pyrazinyl]-2-thiophenesulphonamide

Procedure

Prepared by the method of Example 20b using pyridazine-3-methanol and 5-chloro-N-(3-bromo-5-methyl-2-pyrazinyl)-2-thiophenesulphonamide (Example 23a).

Workup

  1. customPrepared by the method of Example 20b

Sources & evidence

ORD record
ord-6c629fdb7d37475ba6096b758bd1d447
Source dataset
uspto-grants-2008_08
Patent number
US07410972B2

Linked notes

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