ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride → Ethyl(1r,2s)-2-aminocyclohexanecarboxylate
Reaction equation
Cl.[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH2:13])=[O:6])[CH3:3]>[OH-].[Na+]>[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH2:13])=[O:6])[CH3:3]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Ethyl-cis-2-amino-1-cyclohexanecarboxylate hydrochloride (750 mg) was suspended in 1 N NaOH (pH =12). The aqueous layer was extracted with CH2Cl2, washed with brine, dried over Na2SO4 and evaporated to give the crude ethyl-cis-2-amino- 1-cyclohexanecarboxylate (570 mg).
Workup
- extractionThe aqueous layer was extracted with CH2Cl2
- washwashed with brine
- dry with materialdried over Na2SO4
- customevaporated
Sources & evidence
- ORD record
- ord-0a8bcbe64fde474dac87d58794b79a2c
- Source dataset
- uspto-grants-2008_08
- Patent number
- US07411093B2
Reaction notes
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