(4-Bromophenyl)boronic acid → HCID 23725325, compound
Reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[C:7]([C:12]3[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=3)=[N:8][O:9][C:10]=2[CH3:11])[N:3]=[CH:2]1.[Br:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[Br:19][C:20]1[CH:25]=[CH:24][C:23]([N:1]2[CH:5]=[C:4]([C:6]3[C:7]([C:12]4[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=4)=[N:8][O:9][C:10]=3[CH3:11])[N:3]=[CH:2]2)=[CH:22][CH:21]=1Participants
3
Procedure
As described for Example 3, 4-(1H-imidazol-4-yl)-5-methyl-3-(4-fluorophenyl)-isoxazole (73 mg, 0.3 mmol) was converted, using 4-bromophenylboronic acid instead of 4-fluorophenylboronic acid, to the title compound (15 mg, 13%) which was obtained as an off-white solid. MS: m/e=399.6[M+H]+.
Sources & evidence
- ORD record
- ord-1371c9be4c2f446a8a939cb0a4b2cc22
- Source dataset
- uspto-grants-2008_08