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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2220132Generated: October 26, 2026

(2R)-5'-bromo-3'H-spiro[4-azabicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine] → (2'R)-5'-(Benzofuran-3-yl)spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine]

https://huagongshe.com/reaction/2220132

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-5'-bromo-3'H-spiro[4-azabicyclo[2.2.2]octane-2,2'-furo[2,3-b]pyridine]HCID 54506690—
Reactant3-Tri-n-butylstannylbenzofuranHCID 68615772—
Product(2'R)-5'-(Benzofuran-3-yl)spiro[1-azabicyclo[2.2.2]octane-3,2'(3'H)-furo[2,3-b]pyridine]HCID 10404519—

Reaction Steps

Prepared by a method analogous to that described for the preparation of Example 4 from (2′R)-5′-bromospiro[1-azabicyclo[2.2.2]octane-3,2′(3′H)-furo[2,3-b]pyridine] and 3-tri-n-butylstannylbenzofuran. The title compound was obtained as a colourless solid; m/e 333 (MH+).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07417049B2
Source datasetuspto-grants-2008_08
ORD IDord-d313a48f61d64c59a329a8ec918a6b31
Source noteuspto-grants-2008_08