Pyridinium chloride → Benzo[d]isothiazol-7-ol

Reaction equation

S1C2=CC=CC(O)=C2C=N1.C[O:12][C:13]1[C:21]2[S:20][N:19]=[CH:18][C:17]=2[CH:16]=[CH:15][CH:14]=1.Cl.N1C=CC=CC=1>>[S:20]1[C:21]2[C:13]([OH:12])=[CH:14][CH:15]=[CH:16][C:17]=2[CH:18]=[N:19]1

Participants

Reactant 3

HCID 10176127Pyridinium chloride

HCID 13123247HCID 13123247, compound

HCID 135741992Benzo[d]isothiazol-4-ol

Product 1

HCID 19384356Benzo[d]isothiazol-7-olYield 47.4%

Procedure

A method similar to that used in the preparation of benzo[d]isothiazol-4-ol using 7-methoxy-benzo[d]isothiazole (60 mg, 0.363 mmol) and pyridine hydrochloride (500 mg, 4.33 mmol) gave the title compound (26 mg, 47%); Mass spectrum (ion-spray): m/z=151.9 (m+1).

Sources & evidence

ORD record: ord-a7499d459c784f2397ce67f241b95d97
Source dataset: uspto-grants-2008_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07417064B2

Reaction notes

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