2,2-Dimethyl-3-oxobutanenitrile → HCID 69140201, compound

Reaction equation

[CH3:1][C:2]([CH3:8])([C:5](=[O:7])[CH3:6])[C:3]#[N:4].[Cl:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[CH:12][C:11]=1[O:18][CH3:19]>>[Cl:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=[CH:6][C:5](=[O:7])[C:2]([CH3:8])([CH3:1])[C:3]#[N:4])=[CH:12][C:11]=1[O:18][CH3:19]

Participants

Reactant 2

HCID 124683092,2-Dimethyl-3-oxobutanenitrile

HCID 129097254-Chloro-3-methoxybenzaldehyde

Product 1

HCID 69140201HCID 69140201, compound

Procedure

The title compound was prepared from 2,2-dimethyl-3-oxo-butyronitrile {J. K. Rasmussen et al., Synthesis, 1973, 682} and 4-chloro-3-methoxy-benzaldehyde (F. Claudi et al., J. Med. Chem., 1992, 35, 4408) as described in Example 1 Step 1; MS (ES−) m/e 263, 265 [M−H]−.

Sources & evidence

ORD record: ord-78ccd5ea51684a2da23e3dc4e4f5c305
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07375105B2

Reaction notes

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