Reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH3:10]O>>[CH3:10][O:5][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[OH:1]Participants
3
Procedure
A solution of 2-hydroxybenzyl alcohol (5 g, 40 mmol) in methanol (25 mL) was heated in a sealed vessel at 150° C. for 4 hours. The reaction mixture was then concentrated in vacuo and the residue was purified by fractional distillation (90° C./10 mm Hg) to afford the title compound as a colourless liquid in 58% yield, 3.22 g. LRMS APCI m/z 137 [M−H]−
Workup
- concentrationThe reaction mixture was then concentrated in vacuo
- distillationthe residue was purified by fractional distillation (90° C./10 mm Hg)
Sources & evidence
- ORD record
- ord-267c851da28047c39545a7f78252d4fe
- Source dataset
- uspto-grants-2012_06
- Patent number
- US08207198B2
Linked notes
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