Ammonia → 3-Methyl-2-nitrobenzamide

HRID 2223749

Reaction equation

HRID 2223749 reaction equation
[CH3:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5](OC)=[O:6].[NH3:15]>CO>[CH3:1][C:2]1[C:3]([N+:12]([O-:14])=[O:13])=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([NH2:15])=[O:6]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 79621Benzoic acid, 3-methyl-2-nitro-, methyl ester

Product 1

HCID 32713713-Methyl-2-nitrobenzamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
100 °C

Procedure

Methyl 3-methyl-2-nitrobenzoate (10.02 g, 51.3 mmol) was added to a 7N solution of ammonia in methanol (50 mL) and the mixture was heated at 100° C. in a Fisher-Porter tube for 3 hours. The solution was then cooled, concentrated and triturated with dichloromethane to give the title compound of Step A as a white solid (14 g).

Workup

  1. temperatureThe solution was then cooled
  2. concentrationconcentrated
  3. customtriturated with dichloromethane

Sources & evidence

ORD record
ord-056bd7b515214900876475b49e95e6cf
Source dataset
uspto-grants-2008_05
Patent number
US07375232B2

Linked notes

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