(2,6-Dichloropyridin-3-yl)methanol → 3-(Bromomethyl)-2,6-dichloropyridine

Reaction equation

ClC1C(CO)=CC=C(Cl)N=1.[Br:11][CH2:12][C:13]1[C:14]([Cl:21])=[N:15][C:16]([Cl:20])=[C:17](F)[CH:18]=1>>[Br:11][CH2:12][C:13]1[C:14]([Cl:21])=[N:15][C:16]([Cl:20])=[CH:17][CH:18]=1

Participants

Reactant 2

HCID 12259932(2,6-Dichloropyridin-3-yl)methanol

HCID 597175733-(Bromomethyl)-2,6-dichloro-5-fluoropyridine

Product 1

HCID 122653943-(Bromomethyl)-2,6-dichloropyridineYield 80%

Procedure

Compound 13B (0.88 g, 80%) was prepared from 13A (0.82 g, 4.6 mmol) using a procedure similar to the synthesis of 1B. HPLC Rt=2.44 min.

Sources & evidence

ORD record: ord-1c1b1d9f2abd4e32abc23d47397accaf
Source dataset: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07378426B2

Reaction notes

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