4-Bromomethyl-2-chloro-5-iodo-pyridine → 6-Acetyl-3,9-dichloro-5,6-dihydropyrido[4,3-c][1]benzazocine
Reaction equation
Br[CH2:2][C:3]1[C:8](I)=[CH:7][N:6]=[C:5]([Cl:10])[CH:4]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:21])[CH3:20])=[C:14]([CH:22]=[CH2:23])[CH:13]=1.C(N1C2C=CC=CC=2C=CC2N=C(Cl)C(F)=CC=2C1)(=O)C>>[C:19]([N:18]1[C:15]2[CH:16]=[CH:17][C:12]([Cl:11])=[CH:13][C:14]=2[CH:22]=[CH:23][C:8]2[CH:7]=[N:6][C:5]([Cl:10])=[CH:4][C:3]=2[CH2:2]1)(=[O:21])[CH3:20]Participants
4
Procedure
The title compound was prepared from 25D and 9B in two steps by a route analogous to that used for the preparation of 1D. HPLC Rt=2.836 min; LCMS Found: (M+H)+=319.