HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 22252Generated: October 23, 2026
Ethyl 2-methylacetoacetate → 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one
https://huagongshe.com/en/reaction/22252
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl 2-methylacetoacetate | HCID 701 | — |
| Reactant | 4-Toluamidine | HCID 122754 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one | HCID 135704739 | 85.4% |
Reaction Steps
To a solution of 4-methylbenzamidine (4.4 g) in 30 ml of ethanol was added ethyl 2-methylacetoacetate (6.1 g), and the mixture refluxed for 4 hours, giving a precipitate. The mixture was cooled to 0° C., the solid filtered off, washed with ethanol, and dried under reduced pressure, yielding 6 g of 5,6-dimethyl-2-(4-methylphenyl)-3H-pyrimidin-4-one, m.p. 250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05428037 |
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| Source dataset | uspto-grants-1995_06 |
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| ORD ID | ord-858249ef680649c6831afda0b40f7b35 |
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| Source note | uspto-grants-1995_06 |
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