Bromotrimethylsilane → HCID 11088649, compound
Reaction equation
Br[Si](C)(C)C.C([O:8][P:9]([C:14]1[C:15](=[O:30])[NH:16][C:17]2[C:22]([CH:23]=1)=[CH:21][C:20]([N:24]1[CH:28]=[CH:27][CH:26]=[CH:25]1)=[C:19]([Cl:29])[CH:18]=2)(=[O:13])[O:10]CC)C>C(Cl)Cl>[Cl:29][C:19]1[CH:18]=[C:17]2[C:22]([CH:23]=[C:14]([P:9](=[O:8])([OH:10])[OH:13])[C:15](=[O:30])[NH:16]2)=[CH:21][C:20]=1[N:24]1[CH:25]=[CH:26][CH:27]=[CH:28]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
3.37 ml (25.5 mmol) of bromotrimethylsilane are added to a solution of the compound obtained in Example 27 (1.62 g, 4.25 mmol) in 30 ml of CH2Cl2, and the solution is stirred for 4 hours 30 minutes at room temperature. Evaporation to dryness is carried out, and the residue is taken up in methanol. After complete dissolution, a precipitate is observed to form, and stirring is carried out for 10 minutes at room temperature. Filtration and then rinsing with a small amount of methanol and then ether are carried out to obtain the title product.