HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 6-ethoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 6-ethoxy-7-[3-(methanesulfonyloxy)-propoxy]-2H-1-benzopyran-2-one | HCID 19927740 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-ethoxy-7-[3-(4-phenyl-1-piperazinyl)propoxy]-2H-1-benzopyran-2-one | HCID 9953276 | 76% |
Reaction Steps
Method B (40 h at 50° C.); starting materials: 6-ethoxy-7-[3-(methanesulfonyloxy)-propoxy]-2H-1-benzopyran-2-one (see example 71) and 1-phenylpiperazine; yield 76%; fusion point 116° to 117° C. (from isopropanol). Fumarate: method E; yield 94%; fusion point 185° to 187° C. (from ethanol and acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-a543d73e1b6b42c99603dc6ee57f91b7 |
| Source note | uspto-grants-1995_06 |