HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 7-ethoxy-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | N-(2-Methoxyphenyl)piperazine hydrochloride | HCID 9899402 | — |
| Reactant | 6-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one | HCID 19927734 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7-ethoxy-6-{3-[4-(2-methoxyphenyl)-1-piperazinyl]propoxy}-2H-1-benzopyran-2-one | HCID 19927656 | 49% |
Reaction Steps
Method A (48 h at 60° C.); starting materials: 6-(3-chloropropoxy)-7-ethoxy-2H-1-benzopyran-2-one (example 70) and 1(2-methoxyphenyl)piperazine hydrochloride; yield 49%; fusion point 78°-80° C. (from isopropanol). Fumarate: method E; yield 82%; fusion point 149°-150° C. (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-0fe5b8d6421944b7bb370b3ad06c449c |
| Source note | uspto-grants-1995_06 |