HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Bis(4-fluorophenyl)methyl)piperazine → 7-{3-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]propoxy}-6-methoxy-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Bis(4-fluorophenyl)methyl)piperazine | HCID 152932 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one | HCID 19927657 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 7-{3-[4-(bis(4-fluorophenyl)methyl)-1-piperazinyl]propoxy}-6-methoxy-2H-1-benzopyran-2-one | HCID 19927711 | 76% |
Reaction Steps
Method B (36 h at 60° C.); starting materials: 7-[3-(methanesulfonyloxy)propoxy]-6-methoxy-2H-1-benzopyran-2-one (example 68) and 1-[bis(4-fluorophenyl)methyl]-piperazine; yield 76% Ol. Fumarate: method E; yield 82%; fusion point 200°-202° C. (from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-68a7679b0ce54db087202d42cef063b1 |
| Source note | uspto-grants-1995_06 |