HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Methylumbelliferone | HCID 10748 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Product | 7-methoxy-6-[3-(4-phenyl-1-piperidinyl)propoxy]-2H-1-benzopyran-2-one | HCID 19927702 | 55% |
Reaction Steps
Method A (4 h at 80° C.); starting materials: 6-[3-methanesulfonyloxy)propoxy]-7-methoxy-2H-1-benzopyran-2-one (example 67) and 4-phenylpiperidine; yield 55%; fusion point 123°-125° C. (from isopropanol). Hydrochloride: method G; yield 96%; fusion point 212°-215° C. (from isopropanol and ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-fe7a62813244417eabf620c30a56b95d |
| Source note | uspto-grants-1995_06 |