HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+/-)-7-[2-hydroxy-3-(4-phenyl-1-piperidinyl)-propoxy]-6-methoxy-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Phenylpiperidine | HCID 69873 | — |
| Reactant | 6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one | HCID 19927717 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (+/-)-7-[2-hydroxy-3-(4-phenyl-1-piperidinyl)-propoxy]-6-methoxy-2H-1-benzopyran-2-one | HCID 19927671 | 69% |
Reaction Steps
Method C (27 h at 45° C.); starting materials; 6-methoxy-7-(oxiranylmethoxy)-2H-1-benzopyran-2-one (example 86) and 4-phenylpiperidine; yield 69%; fusion point 114°-115° C. (from isopropanol and ethanol). Hydrochloride: method G; yield 82%; fusion point 202°-205° C. (from isopropanol and ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-e45647eba91c4bf5b53226c678b07b5f |
| Source note | uspto-grants-1995_06 |