HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+/-)-6-[2-hydroxy-3-(4-hydroxy-4-phenyl-1-piperidinyl)propoxy]-7-methoxy-2H-1-benzopyran-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| Reactant | 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one | HCID 19927672 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | (+/-)-6-[2-hydroxy-3-(4-hydroxy-4-phenyl-1-piperidinyl)propoxy]-7-methoxy-2H-1-benzopyran-2-one | HCID 19927673 | 69% |
Reaction Steps
Method C (3 d at 40° C.); starting materials: 7-methoxy-6-(oxiranylmethoxy)-2H-1-benzopyran-2-one and 4-hydroxy-4-phenylpiperidine; yield 69%; fusion point 155°-157° C. (from isopropanol). Hydrochloride: method G; yield 88%; fusion point 202°-203° C. (from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-6c21ad51386049a890bf9e863962f865 |
| Source note | uspto-grants-1995_06 |