3-Aminopropionitrile → 2-(1,3-Benzothiazol-2-yl)ethan-1-amine
Reaction equation
[NH2:1][CH2:2][CH2:3][C:4]#[N:5].N[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[SH:13]>CCO>[S:13]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[N:5]=[C:4]1[CH2:3][CH2:2][NH2:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 50 mg of 3-aminopropionitrile and 596 mg of 2-aminothiophenol in EtOH (15 mL) was heated at reflux for six h. After cooling the solution to room temperature, the reaction was concentrated and the residue was purified by silica gel chromatography to afford the title compound as a red oil. MS (M+H)+=179.1.
Workup
- temperatureat reflux for six h
- concentrationthe reaction was concentrated
- customthe residue was purified by silica gel chromatography
Sources & evidence
- ORD record
- ord-1fd12dcc2a8149c4a2a880aee1a32940
- Source dataset
- uspto-grants-2010_05
- Patent number
- US07709473B2
Reaction notes
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