4-chloro-5-ethyl-1H-pyrrole-2-carboxylic acid → 2-Chloro-6-(4-{[(4-chloro-5-ethyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)isonicotinamide
Reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:15]=[C:16]([Cl:18])[N:17]=2)[C:12]([NH2:14])=[O:13])[CH2:5][CH2:4]1.[Cl:19][C:20]1[CH:21]=[C:22]([C:27](O)=[O:28])[NH:23][C:24]=1[CH2:25][CH3:26]>>[Cl:18][C:16]1[CH:15]=[C:11]([CH:10]=[C:9]([N:6]2[CH2:5][CH2:4][CH:3]([NH:2][C:27]([C:22]3[NH:23][C:24]([CH2:25][CH3:26])=[C:20]([Cl:19])[CH:21]=3)=[O:28])[CH2:8][CH2:7]2)[N:17]=1)[C:12]([NH2:14])=[O:13]Participants
3
Procedure
Title compound was synthesized by an analogous method to Example 18 by coupling 2-(4-aminopiperidin-1-yl)-6-chloroisonicotinamide hydrochloride (Intermediate 70) with 4-chloro-5-ethyl-1H-pyrrole-2-carboxylic acid (Intermediate 71).
Sources & evidence
- ORD record
- ord-d5098d051b6f4e59b6d53dd6bc3c8439