N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide → 4-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide
Reaction equation
NC1C=CC(C(NC2CCN(C)C2)=O)=CC=1OC.[CH2:19]([N:21]1[CH2:26][CH2:25][CH:24]([NH:27][C:28](=[O:40])[C:29]2[CH:34]=[CH:33][C:32]([N+:35]([O-])=O)=[C:31]([O:38][CH3:39])[CH:30]=2)[CH2:23][CH2:22]1)[CH3:20]>>[NH2:35][C:32]1[CH:33]=[CH:34][C:29]([C:28]([NH:27][CH:24]2[CH2:23][CH2:22][N:21]([CH2:19][CH3:20])[CH2:26][CH2:25]2)=[O:40])=[CH:30][C:31]=1[O:38][CH3:39]Participants
3
Procedure
The title compound was prepared in quantitative yield by an analogous method to the preparation of Intermediate 187, on a 2 g scale utilising N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide (Intermediate 191).
Sources & evidence
- ORD record
- ord-8f69364c5a0d432089c8a5d9111f677e
- Source dataset
- uspto-grants-2010_05