HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 2,3-dihydro-7-methoxy-8-{3-[4-(3-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | N-(3-methoxyphenyl)piperazine | HCID 81430 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| Solvent | Acetone | HCID 180 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2,3-dihydro-7-methoxy-8-{3-[4-(3-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927679 | 58% |
Reaction Steps
Method B (60 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(3-methoxyphenyl)piperazine; yield 58%; fusion point 130°-132° C. (from ethanol and isopropanol). Fumarate: method E; yield 80%; fusion point 174°-175° C. (from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-eb759a0b34b746ed8ab96923d5d5c27c |
| Source note | uspto-grants-1995_06 |