N-{5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide → 5-[cis-3,5-Dimethyl-1-piperazinyl]-3-pyridinamine
Reaction equation
[CH3:1][C@H:2]1[N:7](CC2C=CC=CC=2)[C@@H:6]([CH3:15])[CH2:5][N:4]([C:16]2[CH:17]=[C:18]([NH2:24])[C:19](OC)=[N:20][CH:21]=2)[CH2:3]1.C[C@H]1N[C@@H](C)CN(C2C=C(NC(=O)C(F)(F)F)C=NC=2)C1>>[CH3:1][C@H:2]1[NH:7][C@@H:6]([CH3:15])[CH2:5][N:4]([C:16]2[CH:17]=[C:18]([NH2:24])[CH:19]=[N:20][CH:21]=2)[CH2:3]1Participants
3
Procedure
The title compound was prepared in a manner similar to 5-[cis-3,5-dimethyl-4-(phenylmethyl)-1-piperazinyl]-2-(methyloxy)-3-pyridinamine (D29) using N-{5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinyl}-2,2,2-trifluoroacetamide (D35) as the starting material.
Sources & evidence
- ORD record
- ord-c1c66408b80d4188af524663a761addf
- Source dataset