HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrophenyl)piperazine → 2,3-dihydro-7-methoxy-8-{3-[4-(4-nitrophenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Reactant | Fumarate | HCID 5460307 | — |
| Reactant | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2,3-dihydro-7-methoxy-8-{3-[4-(4-nitrophenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927668 | 43% |
Reaction Steps
Method B (60 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(4-nitrophenyl)piperazine; yield 43%; fusion point 226°-228° C. (decomposes; from acetone). Fumarate: method E; yield 92%; fusion point 216° C. (decomposes; from acetone).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428038 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-4fbeac3717a44a1b98fa1cdb5f7bd5dd |
| Source note | uspto-grants-1995_06 |