HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → [6-(Hydroxymethyl)pyridin-3-yl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydride | HCID 166653 | — |
| Reactant | 2,5-Di(acetoxymethyl)pyridine | HCID 20263986 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | [6-(Hydroxymethyl)pyridin-3-yl]methanol | HCID 820251 | — |
Reaction Steps
2,5-Di(acetoxymethyl)pyridine (0.05 mole) is reduced with lithium aluminum hydride (0.025 mole) in tetrahydrofuran (50 ml.) at 0° C. with stirring. After one hour, water is added to decompose excess hydride, and the mixture is concentrated to dryness. The residue is extracted with hot isopropanol (2×60 ml.) and the extract is concentrated to dryness to give 2,5-di(hydroxymethyl)pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04355034 |
| Source dataset | uspto-grants-1982_10 |
| ORD ID | ord-5cdfdb96128d45b2bb3d6281723a2237 |
| Source note | uspto-grants-1982_10 |