(2S)-3,3-dimethylbutan-2-amine → N-((1S)-1,2,2-trimethylpropyl)-3-fluoro-4-(2-propynyloxy)benzamide

HRID 2236353

Reaction equation

HRID 2236353 reaction equation
[CH3:1][C@H:2]([NH2:7])[C:3]([CH3:6])([CH3:5])[CH3:4].[CH2:8]([O:11][C:12]1[CH:20]=[CH:19][C:15]([C:16](Cl)=[O:17])=[CH:14][C:13]=1[F:21])[C:9]#[CH:10]>>[CH3:1][C@H:2]([NH:7][C:16](=[O:17])[C:15]1[CH:19]=[CH:20][C:12]([O:11][CH2:8][C:9]#[CH:10])=[C:13]([F:21])[CH:14]=1)[C:3]([CH3:6])([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 7004913(2S)-3,3-dimethylbutan-2-amineHCID 574456843-Fluoro-4-(2-propynyloxy)benzoyl chloride

Product 1

HCID 59301794N-((1S)-1,2,2-trimethylpropyl)-3-fluoro-4-(2-propynyloxy)benzamide

Procedure

According to the same method as that of Production Example 1, (1S)-1,2,2-trimethylpropylamine was used in place of 2,2-dimethylpropylamine, and 4-(2-propynyloxy)-3-fluorobenzoyl chloride was used in place of 4-(2-propynyloxy)-3-methoxybenzoyl chloride to obtain N-((1S)-1,2,2-trimethylpropyl)-3-fluoro-4-(2-propynyloxy)benzamide (hereinafter, described as the compound 25 of the present invention) represented by the formula:

Sources & evidence

ORD record
ord-0b249d97cbc14cc49f1af2aeb8cba472
Source dataset
uspto-grants-2010_05
Patent number
US07714168B2

Linked notes

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