HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-5-methylbenzoic acid → 2-Carboxy-4-methylcyclohexan-1-yl-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-5-methylbenzoic acid | HCID 76255 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Ruthenium carbon | HCID 16218582 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Carboxy-4-methylcyclohexan-1-yl-amine | HCID 14993976 | — |
Reaction Steps
50 g (0.33 mol) of 2-amino-5-methyl-benzoic acid, dissolved in 100 ml of tetrahydrofuran, are hydrogenated for 14 hours at 200° C. and 200 bar hydrogen in the presence of 5 g of ruthenium/charcoal. After cooling and evaporation, 30 g o f 2-carboxy-4-methyl-cyclohexan-1-yl -amine are obtained as a pale oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05428073 |
| Source dataset | uspto-grants-1995_06 |
| ORD ID | ord-7803faf4114942328d46e35a1e9d6188 |
| Source note | uspto-grants-1995_06 |