P-Anisidine → 4-chloro-N-(4-methoxyphenyl)-2-nitrobenzamide

HRID 2242870

Reaction equation

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([NH2:22])=[CH:18][CH:17]=1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:22][C:19]2[CH:20]=[CH:21][C:16]([O:15][CH3:14])=[CH:17][CH:18]=2)=[O:8])=[C:4]([N+:11]([O-:13])=[O:12])[CH:3]=1

Participants

Reactant 2

HCID 7732P-Anisidine

HCID 804754-Chloro-2-nitrobenzoic acid

Product 1

HCID 7891784-chloro-N-(4-methoxyphenyl)-2-nitrobenzamideYield 92.4%

Procedure

The title compound was prepared from 4-chloro-2-nitro-benzoic acid (6.0 g, 30 mmol) and p-anisidine (4.0 g, 33 mmol) using the procedure of step 1 of the Example 1 to provide the title compound (8.5 g, 90%).

Sources & evidence

ORD record: ord-8e0b4fa076c04dc5a01e27cb954d2096
Source dataset: uspto-grants-2010_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07674802B2

Linked notes

Loading…