Benzoyl chloride → Benzamide, N-(2-(2,3-dihydro-6-methoxy-1H-inden-5-yl)ethyl)-

HRID 224332

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1C)[CH2:9][CH2:8][CH2:7]2.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[C:23](=O)([O-])[O-:24].[Na+].[Na+]>>[C:14]([NH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][C:12]=1[O:24][CH3:23])[CH2:9][CH2:8][CH2:7]2)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

Reactant 3

HCID 7412Benzoyl chloride

HCID 10340Sodium Carbonate

HCID 124261245-Aminoethyl-6-methylindan

Product 1

HCID 3051192Benzamide, N-(2-(2,3-dihydro-6-methoxy-1H-inden-5-yl)ethyl)-

Procedure

The procedure of Example 1 was followed in reacting 5-aminoethyl-6-methylindan with benzoylchloride, using sodium carbonate in place of triethylamine, to produce the desired product. After recrystallization from ether the product melted at 104°-106° C.

Sources & evidence

ORD record: ord-123a62465b0e4b039014d8fd1fb331c9
Source dataset: uspto-grants-1980_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04232014

Linked notes

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