7,8-difluoro-2-pentyl-2H-chromene → 7,8-Difluoro-2-pentyl-3,4-dihydro-2H-1-benzopyran
Reaction equation
[F:1][C:2]1[C:11]([F:12])=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[O:9]2)=[CH:4][CH:3]=1>C1(C)C=CC=CC=1.[Pd]>[F:1][C:2]1[C:11]([F:12])=[C:10]2[C:5]([CH2:6][CH2:7][CH:8]([CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[O:9]2)=[CH:4][CH:3]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
51.0 g (0.21 mol) of 7,8-difluoro-2-pentyl-2H-chromene are hydrogenated for 1 h at room temperature in 510 ml of toluene in the presence of Pd/C (5% Pd). The batch is concentrated to dryness. The crude product (yellowish liquid) can be used directly for the next step.
Workup
- concentrationThe batch is concentrated to dryness
Sources & evidence
- ORD record
- ord-ca755439fb5045dcb9ae84d32c68a691
- Source dataset
- uspto-grants-2010_03
- Patent number
- US07678929B2
Reaction notes
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