Benzylamine → n-Heptyl-3-benzyl thiourea

HRID 224631

Reaction equation

HRID 224631 reaction equation
[CH2:1]([N:8]=[C:9]=[S:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[CH2:11]([NH2:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1C=CC=CC=1>[CH2:1]([NH:8][C:9]([NH:18][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[S:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 78152Heptane, 1-isothiocyanato-

Product 1

HCID 12796256n-Heptyl-3-benzyl thioureaYield 105.9%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 3.1 grams (0.02 mole) of n-heptyl isothiocyanate dissolved in 25 milliliters of benzene, was added 2.1 grams (0.02 mole) benzylamine. The resulting exothermic reaction resulted in a temperature rise from 24° C. to 35° C. The mixture was then refluxed for 20 minutes on the steam-bath until the mixture reaced neutral pH and the mixture was evaporated under vacuum to yield 5.6 grams of n-heptyl-3-benzyl thiourea, ND30 =1.5513.

Workup

  1. customThe resulting exothermic reaction
  2. customresulted in a temperature rise from 24° C. to 35° C
  3. temperatureThe mixture was then refluxed for 20 minutes on the steam-bath until the mixture
  4. customthe mixture was evaporated under vacuum

Sources & evidence

ORD record
ord-0c0def6dcc7143ae97ab10dee4b9a77a
Source dataset
uspto-grants-1980_11
Patent number
US04233318

Linked notes

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