1-Methyl-3-aminopyrazole → HCID 23160293, compound
Reaction equation
Cl[C:2]1[C:7]([CH2:8][F:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=1.Cl[C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[C:25]([OH:28])[CH:26]=2)[N:21]=[CH:20][N:19]=1>>[F:9][CH2:8][C:7]1[C:2]([O:28][C:25]2[CH:26]=[C:27]3[C:22](=[CH:23][CH:24]=2)[N:21]=[CH:20][N:19]=[C:18]3[NH:10][C:11]2[CH:15]=[CH:14][N:13]([CH3:16])[N:12]=2)=[N:3][CH:4]=[CH:5][CH:6]=1Participants
4
Procedure
The compound of Example 125 was manufactured by the same method as in Example 95, by a similar method thereto or by a combination of such a method with a conventional method using 2-chloro-3-fluoromethylpyridine, 3-amino-1-methyl-1H-pyrazole and 4-chloro-6-hydroxy-quinazoline.
Sources & evidence
- ORD record
- ord-1e4e23790b2b4e21b727d8c5a4956282