Pilocarpine → Pilocarpine Alpha Tocopherol Hemisuccinate

HRID 2248545

Reaction equation

HRID 2248545 reaction equation
[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.[CH3:16][C:17]1[C:22]([CH3:23])=[C:21]([O:24][C:25]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:26])[C:20]([CH3:32])=[C:19]2[CH2:33][CH2:34][C@:35]([CH2:38][CH2:39][CH2:40][C@@H:41]([CH2:43][CH2:44][CH2:45][C@@H:46]([CH2:48][CH2:49][CH2:50][CH:51]([CH3:53])[CH3:52])[CH3:47])[CH3:42])([CH3:37])[O:36][C:18]=12.CC1C(C)=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C)C=1O>C(Cl)Cl>[CH3:1][CH2:2][C@@H:3]1[C:7](=[O:8])[O:6][CH2:5][C@@H:4]1[CH2:9][C:10]1[N:14]([CH3:15])[CH:13]=[N:12][CH:11]=1.[CH3:16][C:17]1[C:22]([CH3:23])=[C:21]([O:24][C:25]([CH2:27][CH2:28][C:29]([OH:31])=[O:30])=[O:26])[C:20]([CH3:32])=[C:19]2[CH2:33][CH2:34][C@:35]([CH2:38][CH2:39][CH2:40][C@@H:41]([CH2:43][CH2:44][CH2:45][C@@H:46]([CH2:48][CH2:49][CH2:50][CH:51]([CH3:53])[CH3:52])[CH3:47])[CH3:42])([CH3:37])[O:36][C:18]=12

Participants

5

Reactant 3

HCID 5910Pilocarpine2×HCID 14985alpha-TocopherolHCID 20353alpha-Tocopherol succinate

Product 1

HCID 131716046Pilocarpine Alpha Tocopherol Hemisuccinate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The materials and procedures of Example 9 were followed using a 5.0 liter round bottom flask and stopper, 30 g of pilocarpine base, 76.5 g of D-alpha-tocopherol acid succinate (corresponding to a 1:1 M ratio of pilocarpine:D-alpha-tocopherol), and 300 ml of methylene chloride.

Sources & evidence

ORD record
ord-ed9946982a3448c08c294428de584b25
Source dataset
uspto-grants-1991_08
Patent number
US05041278

Linked notes

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