Methanol → Methyl 3-hydroxy-4-methyl-5-methoxythiophene-2-carboxylate

Reaction equation

Cl[C:2]1([C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:7])[C:5]([CH3:8])=[CH:4][S:3]1.[CH3:13][OH:14]>>[OH:7][C:6]1[C:5]([CH3:8])=[C:4]([O:14][CH3:13])[S:3][C:2]=1[C:9]([O:11][CH3:12])=[O:10]

Participants

Reactant 2

HCID 887Methanol

HCID 14642334Methyl 2-chloro-4-methyl-3-oxo-2,3-dihydrothiophene-2-carboxylate

Product 1

HCID 54710752Methyl 3-hydroxy-4-methyl-5-methoxythiophene-2-carboxylate

Procedure

The product of (d) above (3 g) was dissolved in 15 ml of methanol and stirred 8 hours at room temperature. The precipitate was filtered and recrystallised from methanol, m.p. 63°-65° C.

Workup

filtrationThe precipitate was filtered
customrecrystallised from methanol, m.p. 63°-65° C.

Sources & evidence

ORD record: ord-295e2efad9a74dfe90703e0c11c85f6c
Source dataset: uspto-grants-1991_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05041461

Reaction notes

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