Sodium Cyanide → alpha-Oxothiophen-2-acetonitrile
Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[O:10])[C:7](O)=O.S1C=CC=C1C(Cl)=O.[C-]#[N:20].[Na+]>C(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:7]#[N:20])=[O:10]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A process for preparing thienylglyoxylic acid which comprises reacting thiophene carboxylic acid chloride with aqueous sodium cyanide in methylene chloride solvent and in the presence of a phase transfer catalyst to form thiophene carboxylic acid cyanide and then reacting said thiophene carboxylic acid cyanide with concentrated hydrochloric acid at a temperature and for a time sufficient to form thienylglyoxylic acid.
Sources & evidence
- ORD record
- ord-00e6599292844ef0b8b889a075c4bd4e
- Source dataset
- uspto-grants-1980_11
- Patent number
- US04234737
Reaction notes
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