Sodium Cyanide → alpha-Oxothiophen-2-acetonitrile

HRID 224942

Reaction equation

HRID 224942 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](Cl)=[O:7].[C-:9]#[N:10].[Na+]>C(Cl)Cl>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:9]#[N:10])=[O:7]

Participants

4

Reactant 2

HCID 8929Sodium CyanideHCID 789282-Thiophenecarbonyl chloride

Product 1

HCID 80107alpha-Oxothiophen-2-acetonitrile

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A process for preparing thienylglyoxamide which comprises reacting thiophene carboxylic acid chloride with aqueous sodium cyanide in methylene chloride solvent and in the presence of a phase transfer catalyst to form thiophene carboxylic acid cyanide and reacting said thiophene carboxylic acid cyanide with concentrated hydrochloric acid at a temperature and for a time sufficient to form thienylglyoxamide.

Workup

  1. customA process for preparing thienylglyoxamide which

Sources & evidence

ORD record
ord-6f4fb7a1d88f4025bff541cf774a000c
Source dataset
uspto-grants-1980_11
Patent number
US04234737

Linked notes

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