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Hydrazine → HCID 178498204, compound

HRID 2249519
Notes
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Reaction equation

HRID 2249519 reaction equation
[CH3:1][O:2][C:3]([C:5]1[N:6]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=[C:8]([C:10](=S)[NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:13]=2[F:19])[CH:9]=1)=[O:4].[NH2:25][NH2:26]>C(Cl)Cl.CCO>[CH3:1][O:2][C:3]([C:5]1[N:6]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:7]=[C:8]([C:10](=[N:25][NH2:26])[NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([F:18])[C:13]=2[F:19])[CH:9]=1)=[O:4]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 9321HydrazineHCID 586858224-(2,3-Difluoro-phenylthiocarbamoyl)-1-methanesulfonyl-1H-pyrrole-2-carboxylic acid methyl ester

Product 1

HCID 178498204HCID 178498204, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-(2,3-difluoro-phenylthiocarbamoyl)-1-methanesulfonyl-1H-pyrrole-2-carboxylic acid methyl ester (420 mg, 1.12 mmol) in CH2Cl2 (5 mL) and EtOH (5 mL) was added NH2NH2 (50 mg, 1.56 mmol) at room temperature. The mixture was stirred for 3 hours and the solvents were removed by evaporation under reduced pressure. The crude yellow solid product (410 mg, 98%) was dried on the pump for direct use. MS (ES+): m/e=373.1 (M+H); LC/Method A/2.70 min.

Workup

  1. customthe solvents were removed by evaporation under reduced pressure
  2. dry with materialThe crude yellow solid product (410 mg, 98%) was dried on the pump for direct use
  3. customLC/Method A/2.70 min.

Sources & evidence

ORD record
ord-912553e535e94980aab455e7f4ae7771
Source dataset
uspto-grants-2008_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07314885B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes