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1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 2-Bromo-4-(2-{(5-ethylpyrimidin-2-yl)[4-(trifluoromethoxy)benzyl]amino}ethyl)phenol

HRID 2251505
Notes
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Reaction equation

HRID 2251505 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][NH:12][C:13]2[N:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][N:14]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.[F:21][C:22]([F:33])([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][N:12]([C:13]2[N:18]=[CH:17][C:16]([CH2:19][CH3:20])=[CH:15][N:14]=2)[CH2:28][C:27]2[CH:30]=[CH:31][C:24]([O:23][C:22]([F:21])([F:32])[F:33])=[CH:25][CH:26]=2)[CH:5]=[CH:6][C:7]=1[OH:8]
ParticipantsProcedureSources & evidenceReaction notes

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 59643362N-[2-(3-Bromo-4-methoxyphenyl)ethyl]-5-ethylpyrimidin-2-amine

Product 1

HCID 596431532-Bromo-4-(2-{(5-ethylpyrimidin-2-yl)[4-(trifluoromethoxy)benzyl]amino}ethyl)phenol

Procedure

Similarly prepared from N-[2-(3-bromo-4-methoxyphenyl)ethyl]-5-ethylpyrimidin-2-amine and 4-trifluoromethoxy benzyl bromide.

Sources & evidence

ORD record
ord-7d1736c3c8884a0c8a4c863cfc4174fb
Source dataset
uspto-grants-2008_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07319104B2

Reaction notes

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On this pageParticipantsProcedureSources & evidenceReaction notes