[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:14][CH2:13][N:12](C(OCC)=O)[CH2:11][CH2:10]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+]>O.C(O)C.[Cl-].[Na+]>[C:1]([O:5][C:6]([NH:8][CH:9]1[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]19.91 g (0.073 mol) of the compound from Example 20A are added to a mixture of 32.33 g (0.576 mol) of KOH in 175 ml of water and 175 ml of ethanol and heated to reflux for 4 h. The reaction solution is then stirred at room temperature overnight, diluted with 350 ml of conc. sodium chloride solution and extracted four times with a total of 1500 ml of ethyl acetate. The organic extract is washed four times with 100 ml of sodium chloride solution each time, dried over sodium acetate, concentrated and dried under-high vacuum.
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