2-Amino-1-morpholinoethanone → HCID 69130263, compound
Reaction equation
[NH2:1][CH2:2][C:3]([N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1)=[O:4].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([C:28]2[CH:45]=[CH:44][C:31]([O:32][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](O)=[O:42])=[CH:35][CH:34]=3)=[CH:30][CH:29]=2)[C:23](=[O:27])[N:24]([CH3:26])[CH3:25])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:21]=[C:22]([C:28]2[CH:45]=[CH:44][C:31]([O:32][C:33]3[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](=[O:42])[NH:1][CH2:2][C:3]([N:5]4[CH2:10][CH2:9][O:8][CH2:7][CH2:6]4)=[O:4])=[CH:35][CH:34]=3)=[CH:30][CH:29]=2)[C:23]([N:24]([CH3:26])[CH3:25])=[O:27])[CH:16]=[C:17]([O:19][CH3:20])[CH:18]=1Participants
3
Procedure
Following the general procedure for conversion of carboxylic acids to amides mentioned above and using 2-amino-1-morpholin-4-yl-ethanone as amine, 3-(4-{4-[2-(3,5-dimethoxyphenyl)-1-dimethylcarbamoylvinyl]-phenoxy}-phenyl)-propionic acid, 38, was converted to 63.
Sources & evidence
- ORD record
- ord-eb26ef7399a14cc19a9d89cfe1285ab6
- Source dataset
- uspto-grants-2008_01
- Patent number
- US07323496B2