Diethyl Ether → 2-(2-Furyl)benzyl chloride
Reaction equation
O1C=CC=[C:2]1[C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)CO.S(Cl)([Cl:16])=O.[CH2:18]([O:20][CH2:21][CH3:22])[CH3:19]>>[O:20]1[CH:21]=[CH:22][CH:19]=[C:18]1[C:13]1[CH:12]=[CH:11][CH:8]=[CH:7][C:6]=1[CH2:2][Cl:16]Participants
4
Procedure
160 mg of the resulting alcohol compound was dissolved in 3 ml of anhydrous ethyl ether. Thionyl chloride (73 microliters) was added, and under ice cooling, the mixture was stirred for 3 hours. After the reaction, the reaction mixture was washed with a saturated aqueous solution of sodium chloride and 5% sodium hydrogen carbonate to give an ethyl ether solution of the captioned compound. It was used directly in the reaction of Example 58.
Workup
- customAfter the reaction
- washthe reaction mixture was washed with a saturated aqueous solution of sodium chloride and 5% sodium hydrogen carbonate
- customto give an ethyl ether solution of the captioned compound
- customIt was used directly in the reaction of Example 58
Sources & evidence
- ORD record
- ord-c56edbb658dd4840b4c7c5286e3f2558
- Source dataset
- uspto-grants-1993_08
- Patent number
- US05234946
Reaction notes
Loading…