Ethanol → 5-(3-Methyl-1,2,4-oxadiazol-5-yl)-3-nitropyrocatechol

HRID 2254818

Reaction equation

HRID 2254818 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([C:14]2[O:18][N:17]=[C:16]([CH3:19])[N:15]=2)[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]=1[O:9]C.B(Br)(Br)Br.C(O)C>C(Cl)Cl>[CH3:19][C:16]1[N:15]=[C:14]([C:5]2[CH:4]=[C:3]([OH:2])[C:8]([OH:9])=[C:7]([N+:11]([O-:13])=[O:12])[CH:6]=2)[O:18][N:17]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 25134Boron tribromideHCID 214590805-(3,4-Dimethoxy-5-nitrophenyl)-3-methyl-1,2,4-oxadiazole

Product 1

HCID 1356653125-(3-Methyl-1,2,4-oxadiazol-5-yl)-3-nitropyrocatechol

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

2.5 g of 5-(3,4-dimethoxy-5-nitrophenyl)-3-methyl-1,2,4-oxadiazole are dissolved in 70 ml of methylene chloride. After cooling to -60° there is added dropwise thereto within 20 minutes while stirring a solution of 23.62 g of boron tribromide in 50 ml of methylene chloride, whereupon the mixture is held at the reflux temperature for 48 hours. After cooling to -60°, the mixture is treated with 60 ml of ethanol and subsequently stirred at room temperature for 30 minutes. The yellow solution is evaporated to dryness, whereupon the residue is treated three times with 100 ml of toluene/ethanol (1:1) each time and the solvent is distilled each time. After crystallization from ethanol, there is obtained 5-(3-methyl-1,2,4-oxadiazol-5-yl)-3-nitropyrocatechol in the form of yellow crystals of m.p. 201°-202°.

Workup

  1. temperatureAfter cooling to -60° there
  2. additionis added dropwise
  3. temperatureAfter cooling to -60°
  4. customThe yellow solution is evaporated to dryness, whereupon the residue
  5. additionis treated three times with 100 ml of toluene/ethanol (1:1) each time
  6. distillationthe solvent is distilled each time
  7. customAfter crystallization from ethanol

Sources & evidence

ORD record
ord-c98030cf9ba34d119b01e0cb97c880be
Source dataset
uspto-grants-1993_08
Patent number
US05236952

Linked notes

Loading…