1,3-Benzothiazole-6-sulfonyl chloride → N-(2-Bromo-6-methyl-3-pyridyl)-6-benzothiazolesulfonamide

Reaction equation

[NH2:1][C:2]1[C:3]([Br:9])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[S:10]1[C:14]2[CH:15]=[C:16]([S:19](Cl)(=[O:21])=[O:20])[CH:17]=[CH:18][C:13]=2[N:12]=[CH:11]1>>[Br:9][C:3]1[C:2]([NH:1][S:19]([C:16]2[CH:17]=[CH:18][C:13]3[N:12]=[CH:11][S:10][C:14]=3[CH:15]=2)(=[O:20])=[O:21])=[CH:7][CH:6]=[C:5]([CH3:8])[N:4]=1

Participants

Reactant 2

HCID 27951701,3-Benzothiazole-6-sulfonyl chloride

HCID 144180512-Bromo-6-methylpyridin-3-amine

Product 1

HCID 86622569N-(2-Bromo-6-methyl-3-pyridyl)-6-benzothiazolesulfonamideYield 35%

Procedure

By working in a manner similar to that of Preparation VII, starting with 3-amino-2-bromo-6-methylpyridine and 6-benzothiazolesulfonyl chloride, the expected product is obtained in the form of a beige-colored paste (yield=35%).

Sources & evidence

ORD record: ord-a57f06a4edee43388913997c8df6648f
Source dataset: uspto-grants-2009_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07557122B2

Reaction notes

Loading…