Methanol → Phenol, 2-(methoxymethyl)-

HRID 225826

Reaction equation

HRID 225826 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5].[CH3:10]O>>[CH3:10][O:5][CH2:4][C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[OH:1]

Participants

3

Reactant 2

HCID 887MethanolHCID 5146Salicyl Alcohol

Product 1

HCID 182079Phenol, 2-(methoxymethyl)-Yield 58%

Procedure

A solution of 2-hydoxybenzyl alcohol (5 g, 40 mmol) in methanol (25 mL) was heated in a sealed vessel at 150° C. for 4 hours. The reaction mixture was then concentrated in vacuo and the residue was purified by fractional distillation (90° C./10 mm Hg) to afford the title compound as a colourless liquid in 58% yield, 3.22 g. LRMS APCI m/z 137 [M−H]−

Workup

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. distillationthe residue was purified by fractional distillation (90° C./10 mm Hg)

Sources & evidence

ORD record
ord-38038d21591b495f93d7c1895c323680
Source dataset
uspto-grants-2009_07
Patent number
US07557131B2

Linked notes

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